Your kidneys do many important jobs. Some of the ways they keep your whole body in balance include removing natural waste products and extra water from your body, helping make red blood cells, balancing important minerals in your body, helping maintain your blood pressure, keeping your bones healthy. Signs and symptoms of chronic kidney disease develop over time if kidney damage progresses slowly. Loss of kidney function can cause a buildup of fluid or body waste or electrolyte problems. Depending on how severe it is, loss of kidney function can cause nausea, vomiting, loss of appetite, fatigue and weakness, sleep problems, urinating more or less, decreased mental sharpness, muscle cramps, welling of feet and ankles, dry-itchy skin, high blood pressure (hypertension) that's difficult to control, shortness of breath, if fluid builds up in the lungs, chest pain, if fluid builds up around the lining of the heart. Signs and symptoms of kidney disease are often nonspecific. This means they can also be caused by other illnesses. If you are concerned, please make an appointment to see your GP.